TY  - JOUR
TI  - Interplay between DNA methylation, histone modification and chromatin remodeling in stem cells and during development 
AU  - Ikegami, Kohta
AU  - Ohgane, Jun
AU  - Tanaka, Satoshi
AU  - Yagi, Shintaro
AU  - Shiota, Kunio
T2  - The International Journal of Developmental Biology
AB  -  Genes constitute only a small proportion of the mammalian genome, the majority of which is composed of non-genic repetitive elements including interspersed repeats and satellites. A unique feature of the mammalian genome is that there are numerous tissue-dependent, differentially methylated regions (T-DMRs) in the non-repetitive sequences, which include genes and their regulatory elements. The epigenetic status of T-DMRs varies from that of repetitive elements and constitutes the DNA methylation profile genome-wide. Since the DNA methylation profile is specific to each cell and tissue type, much like a fingerprint, it can be used as a means of identification. The formation of DNA methylation profiles is the basis for cell differentiation and development in mammals. The epigenetic status of each T-DMR is regulated by the interplay between DNA methyltransferases, histone modification enzymes, histone subtypes, non-histone nuclear proteins and non-coding RNAs. In this review, we will discuss how these epigenetic factors cooperate to establish cell- and tissue-specific DNA methylation profiles.
PY  - 2009
DO  - 10.1387/ijdb.082741ki
VL  - 53
IS  - 2-3
SP  - 203
EP  - 214
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/082741ki
Y2  - 2024/05/05/05:52:19
ER  -