TY  - JOUR
TI  - Chemical genomics: a key to the epigenome - An interview with Minoru Yoshida 
AU  - Khochbin, Saadi
T2  - The International Journal of Developmental Biology
AB  - The identification and characterization of the first potent histone deacetylase inhibitors constituted a major step, which not only gave a key to researchers worldwide to tackle the unknown universe of cell signalling by protein lysine acetylation, but also opened the way for the development of large series of molecules with important therapeutic properties. Minoru Yoshida, who played a critical role in characterizing the fist potent and specific histone deacetylase inhibitor, trichostatin A, reveals here how and why his work led to this discovery. He also comments on his other outstanding contributions and gives his opinion on the impact of chemical genomics as a key to open the mysteries of the epigenome.
PY  - 2009
DO  - 10.1387/ijdb.082686sk
VL  - 53
IS  - 2-3
SP  - 269
EP  - 274
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/082686sk
Y2  - 2024/05/04/07:53:53
ER  -