TY  - JOUR
TI  - The evolution and maintenance of <i>Hox</i> gene clusters in vertebrates and the teleost-specific genome duplication 
AU  - Kuraku, Shigehiro
AU  - Meyer, Axel
T2  - The International Journal of Developmental Biology
AB  - Hox genes are known to specify spatial identities along the anterior-posterior axis during embryogenesis. In vertebrates and most other deuterostomes, they are arranged in sets of uninterrupted clusters on chromosomes, and are in most cases expressed in a "colinear" fashion, in which genes closer to the 3’-end of the Hox clusters are expressed earlier and more anteriorly and genes close to the 5’-end of the clusters later and more posteriorly. In this review, we summarize the current understanding of how Hox gene clusters have been modified from basal lineages of deuterostomes to diverse taxa of vertebrates. Our parsimony reconstruction of Hox cluster architecture at various stages of vertebrate evolution highlights that the variation in Hox cluster structures among jawed vertebrates is mostly due to secondary lineage-specific gene losses and an additional genome duplication that occurred in the actinopterygian stem lineage, the teleost-specific genome duplication (TSGD).
PY  - 2009
DO  - 10.1387/ijdb.072533km
VL  - 53
IS  - 5-6
SP  - 765
EP  - 773
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/072533km
Y2  - 2024/05/04/04:54:36
ER  -