TY  - JOUR
TI  - The spatio-temporal pattern of testis organogenesis in mammals - insights from the mole 
AU  - Carmona, FranciscoD.
AU  - Lupiáñez, DaríoG.
AU  - Martín, José-Ezequiel
AU  - Burgos, Miguel
AU  - Jiménez, Rafael
AU  - Zurita, Federico
T2  - The International Journal of Developmental Biology
AB  - Some cellular events are crucial in testis organogenesis, including Sertoli and Leydig cell differentiation, mesonephric cell migration and testis cord formation. These processes are controlled by transcription factors, paracrine signalling and hormones. Using the mole species Talpa occidentalis as an alternative animal model, we report the expression patterns of nine genes during testis differentiation and analyse their implications in the above-mentioned cellular processes. We show that: 1) Sertoli cell differentiation occurs very early and precedes mesonephric cell migration, indicating that the latter is not needed for the endocrine cytodifferentiation of Sertoli cells; 2) the time of Leydig cell differentiation is consistent with the participation of PDGFR-alpha in promoting the migration and/or proliferation of Leydig cell precursors, and with that of WNT4 signalling in inhibiting Leydig cell differentiation and 3) the formation of the tunica albuginea involves intragonadal cell migration/movement. These results demonstrate that testicular organogenesis in the mole differs from that in the mouse in some particular aspects, thus providing evidence that the spatio-temporal pattern of testis development is not highly conserved during mammalian evolution.
PY  - 2009
DO  - 10.1387/ijdb.072470fc
VL  - 53
IS  - 7
SP  - 1035
EP  - 1044
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/072470fc
Y2  - 2024/05/02/08:02:02
ER  -