TY  - JOUR
TI  - Development of the hair bundle and mechanotransduction
AU  - Nayak, GowriD.
AU  - Ratnayaka, HelenS. K.
AU  - Goodyear, RichardJ.
AU  - Richardson, GuyP.
T2  - The International Journal of Developmental Biology
AB  - This review focuses on the cellular and molecular mechanisms underlying the development of the sensory hair bundle, an apical specialisation of the hair cell that is essential for mechanotransduction. The structure, function and development of the hair bundle is described, with an emphasis on the properties and possible roles played by the different link types that interconnect the individual elements of the hair bundle - the multiple stereocilia and the single kinocilium. Studies of mouse and zebrafish mutants have revealed that several classes of molecule are required for the genesis and maintenance of hair-bundle structure. These include cell surface molecules that are associated with the different hair-bundle links, along with myosin motors, scaffolding proteins and an actin cross-linker. Finally we consider how differences in the form and shape of hair bundles within and between different sensory organs are generated.
PY  - 2007
DO  - 10.1387/ijdb.072392gn
VL  - 51
IS  - 6-7
SP  - 597
EP  - 608
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/072392gn
Y2  - 2024/05/03/07:43:56
ER  -