TY  - JOUR
TI  - Patterning and morphogenesis of the vertebrate inner ear
AU  - Bok, Jinwoong
AU  - Chang, Weise
AU  - Wu, DorisK.
T2  - The International Journal of Developmental Biology
AB  - The positional cues for formation of individual inner ear components are dependent on pre-established axial information conferred by inductive signals from tissues surrounding the developing inner ear. This review summarizes some of the known molecular pathways involved in establishing the three axes of the inner ear, anterior-posterior (AP), dorsal-ventral (DV) and medial-lateral (ML). Signals required to establish the AP axis of the inner ear are not known, but they do not appear to be derived from the hindbrain. In contrast, the hindbrain is essential for establishing the DV axis of the inner ear by providing inductive signals such as Wnts and Sonic hedgehog. Signaling from the hindbrain is also required for the formation of the ML axis, whereas formation of the lateral wall of the otocyst may be a result of first establishing both the AP and DV axes. In addition, this review addresses how genes induced within the otic epithelium as a result of axial specification continue to mediate inner ear morphogenesis.
PY  - 2007
DO  - 10.1387/ijdb.072381jb
VL  - 51
IS  - 6-7
SP  - 521
EP  - 533
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/072381jb
Y2  - 2024/04/29/07:31:11
ER  -