TY  - JOUR
TI  - Developmental expression of <I>Shisa-2</I> in <I>Xenopus laevis</I>
AU  - Silva, Ana-Cristina
AU  - Filipe, Mario
AU  - Vitorino, Marta
AU  - Steinbeisser, Herbert
AU  - Belo, Jose-Antonio
T2  - The International Journal of Developmental Biology
AB  - Shisa is an antagonist of Wnt and FGF signaling, that functions cell autonomously in the endoplasmic reticulum (ER) to inhibit the post-translational maturation of Wnt and FGF receptors. In this paper we report the isolation of a second Xenopus shisa gene (Xshisa-2). Xenopus Shisa-2 shows 30.7% identity to Xshisa. RT-PCR analysis indicated that Xshisa-2 mRNA is present throughout early development and shows an increased expression during neurula and tailbud stages. At neurula stages Xenopus shisa-2 is initially expressed in the presomitic paraxial mesoderm and later in the developing somites. The expression profiles and pattern of Xshisa and Xshisa-2 differ significantly. During gastrulation only Xshisa mRNA is present in the Spemann-Mangold organizer and later on becomes restricted to the neuroectoderm and the prechordal plate.
PY  - 2006
DO  - 10.1387/ijdb.062141as
VL  - 50
IS  - 6
SP  - 575
EP  - 579
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/062141as
Y2  - 2024/05/03/17:06:12
ER  -