TY  - JOUR
TI  - Proliferation and apoptosis in early molar morphogenesis - voles as models in odontogenesis 
AU  - Setkova, Jana
AU  - Lesot, Herve
AU  - Matalova, Eva
AU  - Witter, Kirsti
AU  - Matulova, Petra
AU  - Misek, Ivan
T2  - The International Journal of Developmental Biology
AB  - Proliferation and apoptosis play crucial roles in the development of multicellular organisms. Their precise balance is necessary for tissue homeostasis throughout life. The developing dentition is a suitable model to study proliferation and apoptosis during embryogenesis, but the corresponding studies have been carried out principally in the mouse. The present study aimed to examine proliferation and apoptosis in the vole (Microtus sp., Rodentia) during the early morphogenesis of the first upper molar and compare it to what is known from the mouse. To this end, apoptosis and proliferation were investigated using histology and computer-aided 3D reconstruction. Mitoses accumulated predominantly in the developing cervical loop. Apoptosis during early odontogenesis showed highly specific spatio-temporal patterns in the dental epithelium. Apoptotic bodies were localised in non-dividing cell populations. They accumulated in the same places as described in the mouse: antemolar vestiges (ED 12.5 ­ 15.5), enamel knot (ED 14.5 ­ 15.5), stalk and palatally along the whole first molar tooth germ longitudinal axis (ED 15 - 15.5). Early tooth development in the field vole, including the distribution of apoptosis and mitosis, is very similar to that reported in the mouse, with the exception of the antemolar region. The microtine antemolar vestige is preserved longer than the murine one. It is conceivable that additional distinct differences in morphogenetic processes appear later in tooth development.
PY  - 2006
DO  - 10.1387/ijdb.052067js
VL  - 50
IS  - 5
SP  - 481
EP  - 489
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/052067js
Y2  - 2024/05/03/17:13:53
ER  -