TY  - JOUR
TI  - Expression of <I>FoxP2 </I>during zebrafish development and in the adult brain
AU  - Shah, Rina
AU  - Medina-Martinez, Olga
AU  - Chu, Li-Fang
AU  - Samaco, RodneyC.
AU  - Jamrich, Milan
T2  - The International Journal of Developmental Biology
AB  - Fox (forkhead) genes encode transcription factors that play important roles in the regulation of embryonic patterning as well as in tissue specific gene expression. Mutations in the human FOXP2 gene cause abnormal speech development. Here we report the structure and expression pattern of zebrafish FoxP2. In zebrafish, this gene is first expressed at the 20-somite stage in the presumptive telencephalon. At this stage there is a significant overlap of FoxP2 expression with the expression of the emx homeobox genes. However, in contrast to emx1, FoxP2 is not expressed in the pineal gland or in the pronephric duct. After 72 hours of development, the expression of zebrafish FoxP2 becomes more complex in the brain. The developing optic tectum becomes the major area of FoxP2 expression. In the adult brain, the highest concentrations of the FoxP2 transcript can be observed in the optic tectum. In the cerebellum, only the caudal lobes show high levels of Foxp2 expression. These regions correspond to the vestibulocerebellum of mammals. Several other regions of the brain also show high levels of Foxp2 expression.
PY  - 2006
DO  - 10.1387/ijdb.052065rs
VL  - 50
IS  - 4
SP  - 435
EP  - 438
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/052065rs
Y2  - 2024/04/29/04:53:26
ER  -