TY  - JOUR
TI  - PBX1 intracellular localization is independent of MEIS1 in epithelial cells of the developing female genital tract
AU  - Dintilhac, Agnes
AU  - Bihan, Rejane
AU  - Guerrier, Daniel
AU  - Deschamps, Stephane
AU  - Bougerie, Heloise
AU  - Watrin, Tanguy
AU  - Bonnec, Georgette
AU  - Pellerin, Isabelle
T2  - The International Journal of Developmental Biology
AB  - While studies have highlighted the role of HOXA9-13  and PBX1  homeobox genes during the development of the female genital tract, the molecular mechanisms triggered by these genes are incompletely elucidated. In several developmental pathways, PBX1 binds to MEINOX family members in the cytoplasm to be imported into the nucleus where they associate with HOX proteins to form a higher complex that modulates gene expression. This concept has been challenged by a recent report showing that in some cell cultures, PBX1 nuclear localization might be regulated independently of MEINOX proteins (Kilstrup-Nielsen et al., 2003). Our work gives the first illustration of this alternative mechanism in an organogenesis process. Indeed, we show that PBX1 is mostly cytoplasmic in epithelial endometrial cells of the developing female genital tract despite the nuclear localization of MEIS1. We thus provide evidence for a control of PBX1 intracellular distribution which is independent of MEINOX proteins, but is cell cycle correlated.
PY  - 2005
DO  - 10.1387/ijdb.052013ad
VL  - 49
IS  - 7
SP  - 851
EP  - 858
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/052013ad
Y2  - 2024/05/05/18:25:37
ER  -