TY  - JOUR
TI  - The homeobox gene Msx in development and transdifferentiation of jellyfish striated muscle
AU  - Galle, Sabina
AU  - Yanze, Nathalie
AU  - Seipel, Katja
T2  - The International Journal of Developmental Biology
AB  - Bilaterian Msx  homeobox genes are generally expressed in areas of cell proliferation and in association with multipotent progenitor cells. Likewise, jellyfish Msx  is expressed in progenitor cells of the developing entocodon, a cell layer giving rise to the striated and smooth muscles of the medusa. However, in contrast to the bilaterian homologs, Msx  gene expression is maintained at high levels in the differentiated striated muscle of the medusa in vivo  and in vitro. This tissue exhibits reprogramming competence. Upon induction, the Msx  gene is immediately switched off in the isolated striated muscle undergoing transdifferentiation, to be upregulated again in the emerging smooth muscle cells which, in a stem cell like manner, undergo quantal cell divisions producing two cell types, a proliferating smooth muscle cell and a differentiating nerve cell. This study indicates that the Msx protein may be a key component of the reprogramming machinery responsible for the extraordinary transdifferentation and regeneration potential of striated muscle in the hydrozoan jellyfish.
PY  - 2005
DO  - 10.1387/ijdb.052009sg
VL  - 49
IS  - 8
SP  - 961
EP  - 967
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/052009sg
Y2  - 2024/05/14/15:06:07
ER  -