TY  - JOUR
TI  - Collective cell migration in morphogenesis and cancer
AU  - Friedl, Peter
AU  - Hegerfeldt, Yael
AU  - Tusch, Miriam
T2  - The International Journal of Developmental Biology
AB  - The movement of cells that maintain cell-cell junctions yet protrude along or 
within tissues is an important mechanism for cell positioning in morphogenesis, tissue repair and 
cancer. Collective cell migration shares similarities but also important differences to individually migrating cells. Coherent groups of cells are arranged and held together by cell-cell adhesion molecules, including cadherins, integrins, ALCAM and NCAM. Integrins of the β1 and β3 families further provide polarized interactions with the extracellular tissue environment, while matrix-degrading proteases become focalized to substrate contacts to widen tissue space for the advancing cell mass. By generating one functional unit, in contrast to individual cell migration, collective migration provides the active and passive translocation of mobile and non-mobile cells, respectively. 
This review highlights cellular and molecular principles of collective migration in the context 
of morphogenic tissue patterning and tumor cell invasion.
PY  - 2004
DO  - 10.1387/ijdb.041821pf
VL  - 48
IS  - 5-6
SP  - 441
EP  - 449
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/041821pf
Y2  - 2024/04/30/05:07:33
ER  -