TY  - JOUR
TI  - The chemokine network in cancer - much more than directing cell movement
AU  - Kulbe, Hagen
AU  - Levinson, NeilR.
AU  - Balkwill, Fran
AU  - Wilson, JuliaL.
T2  - The International Journal of Developmental Biology
AB  - Cytokine and chemokine gradients are central to the directed movement of cells in 
both homeostatic and pathological processes. Most cancers have a complex chemokine network 
which can influence immune responses to the tumor, direct the extent and cellular composition of 
the leukocyte infiltrate and also play a role in angiogenesis. Tumor cells can also hijack the 
chemokine system and gain expression of certain chemokine receptors and respond to specific 
chemokine gradients. Chemokine receptor expression and activation on malignant cells may be central to the growth, survival and migration of cancer cells from the primary tumor. Chemokine receptors, both CC and CXC have been detected on malignant cells and the relevant ligands are 
sometimes expressed at the tumor site and at sites of tumor spread, suggesting a role for the chemokine family in malignant growth and metastasis.
PY  - 2004
DO  - 10.1387/ijdb.041814hk
VL  - 48
IS  - 5-6
SP  - 489
EP  - 496
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/041814hk
Y2  - 2024/05/03/19:08:47
ER  -