TY  - JOUR
TI  - The gene schmalspur functions in mesoderm formation in zebrafish, and interacts with notail and spadetail
AU  - Rojo, C
AU  - Ellertsdottir, E
AU  - Pogoda, HM
AU  - Meyer, D
T2  - The International Journal of Developmental Biology
AB  - The gene schmalspur is involved in the Nodal signalling pathway to maintain the expression of nodal genes during zebrafish development. Mutants for nodal-related genes show a partial loss of axial mesoderm, which is also defective in embryos lacking maternal and zigotic expression of schmalspur. We have generated double mutants of schmalspur with other genes responsible for mesoderm formation and have analyzed the phenotype and the genetic interactions by whole-mount in situ hybridization. In addition, cellular transplant experiments were carried out to determine how schmalspur functions in mesoderm formation. Our results show a close genetic interaction of schmalspur with the T-box genes notail and spadetail, since the axial and paraxial mesoderm of these double mutants were strongly affected, and a non-cell autonomous function for schmalspur in mesoderm formation.
PY  - 2001
VL  - 45
IS  - S1
SP  - S157
EP  - S158
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/01450157
Y2  - 2024/05/14/12:02:58
ER  -