TY  - JOUR
TI  - Adhesion of medial edge epithelium cells is altered in the absence of Transforming Growth Factor beta(3)
AU  - Tudela, C
AU  - Bonelli, R
AU  - Ortega, C
AU  - Formoso, MA
AU  - Martinez, T
AU  - Perez, R
AU  - Maestro, C
AU  - Del Rio, A
AU  - Murillo, J
AU  - Barrio, C
AU  - Martinez-Alvarez, C
T2  - The International Journal of Developmental Biology
AB  - Mutations of the gene of Transforming growth factor beta 3 (TGF-beta (3)) lead to cleft palate in both humans and mice. This cleft seems to be produced by a defect in the adhesion of opposing medial edge epithelia (MEE) when contact between palatal shelves occurs. Using immunohistochesmistry, we demonstrate here that intercellular adhesion is altered in MEE cells of TGF-beta (3) null mutant mice. The most striking features observed in these palates are the irregular distribution of beta -catenin in the cytoplasm, in contrast to the regular and circumferential location found in wild type embryos, and the different expression of vinculin and beta -actin, which is similar to the observed in the wild type oral palatal epithelium, that does not participate in palatal fusion.
PY  - 2001
VL  - 45
IS  - S1
SP  - S101
EP  - S102
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/01450101
Y2  - 2024/05/01/13:32:38
ER  -