TY  - JOUR
TI  - Differentiated horizontal cells seem not to be affected by apoptosis during development of the chick retina
AU  - Mayordomo, R
T2  - The International Journal of Developmental Biology
AB  - Natural occurring cell death has been recognised as a feature of normal vertebrate development (Glucksman, 1951; Saunders, 1966). We have studied the temporal and cellular patterns of cell death in the developing chicken retina using the terminal transferase dUTP nick end-labelling (TUNEL) technique. This technique was combined with other methods to identify dying cells. Fluorescent retrograde tracing of ganglion cells or immunohistochenistry for GABA and TrkA as cell markers were combined with the TUNEL technique. The timing and distribution of dying cells suggest that each neuronal cell type in the retina dies during specific and overlapping periods: ganglion cells first, followed by amacrine cells and bipolar cells. Little cell death could be found among horizontal cells orphotoreceptors. These populations seem to be protected from death. We have previously shown evidence of NGF expression among the horizontal cell population during these stages of development and also a protective role of this factor (Karlsson et al., 2001), which supports the present data.
PY  - 2001
VL  - 45
IS  - S1
SP  - S79
EP  - S80
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/01450079
Y2  - 2024/05/04/20:27:59
ER  -